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(109) evaluated the effects of a preventive EODF regimen on the neurodegenerative phenotype of 5XFAD transgenic mice and found a significant increase in inflammation in the cortex of 5XFAD-EODF mice, with increased glial cell reactivity and/or proliferation, along with increased pro-inflammatory cytokines TNF- , p38 MAPK, and EAAT2, and decreased GAD67, associated with glutamate excitotoxicity, and increased NMDA receptor subunit 2B in the cortex of 5XFAD-EODF mice
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